Tramadol (Contramal Retard 100 mg) and Daridorexant: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Additive CNS depression can cause greater sedation, impaired coordination and daytime impairment.
Clinical significance and safety
Tramadol can add to daridorexant-related CNS depression. The daridorexant label warns about other CNS depressants, including benzodiazepines, opioids and tricyclic antidepressants. A clinician should assess the need for both medicines, and excessive sleepiness, falls or breathing difficulty require prompt assessment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.