Darunavir and Digoxin (Digoxin Sandoz 0.25 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Transporter inhibition increases digoxin exposure.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), digoxin concentrations and clinical effects require monitoring. The prescriber should review kidney function and toxicity symptoms rather than applying an isolated two-drug rule.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.