Phenytoin sodium (Epdantoin 100 mg) and Rilpivirine: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Enzyme induction reduces rilpivirine exposure.
Clinical significance and safety
Oral rilpivirine is contraindicated with the named inducing anticonvulsants or rifampin because reduced antiviral exposure may cause treatment failure and resistance. The HIV prescriber should review the entire regimen; do not independently change either treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.