Erlotinib and Losec (Omeprazole) (Losec 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Proton pump inhibition raises gastric pH and can reduce erlotinib absorption.
Clinical significance and safety
Losec 20 mg suppresses stomach acid and can reduce erlotinib exposure, potentially reducing treatment effectiveness. The erlotinib label recommends avoiding proton pump inhibitors when possible; merely separating the doses may not remove this interaction. Ask the oncology team to review reflux treatment rather than changing either medicine yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.