Clarithromycin (Klacid MR 500 mg) and Methadone: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Inhibition of methadone metabolism may increase opioid exposure.
Clinical significance and safety
Inhibition of methadone metabolism can increase or prolong opioid effects, including breathing suppression; stopping the inhibitor can also change methadone exposure. A prescriber or pharmacist should review the combination; do not independently stop, start or change either medicine.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.