Dronedarone (Multaq) (Dronedarone (Dronedaron)) and Nortriptyline: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
The cardiac electrophysiological effects of dronedarone and a tricyclic antidepressant may increase serious ventricular-arrhythmia risk.
Clinical significance and safety
Dronedarone (Multaq) and Nortriptyline: The cardiac electrophysiological effects of dronedarone and a tricyclic antidepressant may increase serious ventricular-arrhythmia risk. The cited dronedarone product information contraindicates torsadogenic combinations including tricyclic antidepressants; specialist review is required. Heart disease, a slow pulse and low potassium or magnesium can increase concern. A clinician determines whether ECG or electrolyte checks are needed. Fainting or new irregular palpitations require urgent assessment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.