Avanafil and Vardenafil: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Two PDE5 inhibitors may have additive pharmacodynamic effects; combined safety and efficacy have not been established.
Clinical significance and safety
Avanafil and Vardenafil: Do not combine avanafil and vardenafil yourself. Blood-pressure lowering or erection-related adverse effects may increase, while a safe combination regimen has not been established. Have the prescriber review the intended treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.