Abrocitinib and Fluoxetine hydrochloride (Depreks 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Strong CYP2C19 inhibition can increase combined exposure to abrocitinib and active metabolites.
Clinical significance and safety
Depreks 20 mg contains a strong CYP2C19 inhibitor. Abrocitinib exposure can rise, and the label recommends prescriber-directed modification for this inhibitor class. Review adverse effects and the entire medicine list with the treating team; this is a different mechanism from serotonin toxicity.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.