Spironolactone (Aldactone 50 mg) and Methadone: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Opioid-related antidiuretic effect may reduce diuretic response.
Clinical significance and safety
Opioids can reduce the response to a diuretic; the clinician may need to reassess urine output, swelling and blood pressure. A prescriber or pharmacist should review the combination; do not independently stop, start or change either medicine.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.