Amlodipine (Amlokard 5 mg) and Darunavir: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
CYP3A inhibition increases exposure to the named calcium-channel blocker.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), this calcium-channel blocker requires monitoring for increased effects such as low blood pressure. The prescriber should check the exact product and make any necessary change.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.