Clomipramine (Anafranil 25 mg) and Oxycodone: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Combined serotonergic effects can cause serotonin syndrome.
Clinical significance and safety
The combination with clomipramine is covered by the opioid label’s serotonergic-drug warning: serotonin syndrome has been reported with opioids and serotonergic medicines. The prescriber should review the combination and monitor for the effects described; do not adjust the opioid or the other medicine independently.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.