Avanafil and Darunavir: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
The boosted regimen increases PDE5-inhibitor exposure.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), PDE5 inhibitors need indication-specific restrictions. Sildenafil for pulmonary arterial hypertension is contraindicated, avanafil is not recommended, and erectile-dysfunction regimens have separate limits; the prescriber must check exact medicine and purpose.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.