Baricitinib and Probenecid (Probenecid (Probenesid)): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Strong OAT3 inhibition reduces baricitinib renal transport clearance and raises exposure.
Clinical significance and safety
Probenecid (Probenesid) contains probenecid, which increases baricitinib exposure through strong OAT3 inhibition. The baricitinib label recommends a clinician-directed modification, with renal function and indication also considered. Do not apply the same rule to weaker OAT3 inhibitors without supporting evidence.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.