Metoprolol (Beloc ZOK 25 mg) and Imatinib: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Weak CYP2D6 inhibition by imatinib modestly increases metoprolol exposure.
Clinical significance and safety
Beloc ZOK 25 mg contains metoprolol. GLEEVEC reports a modest exposure increase in a clinical study and states that a routine dose adjustment was not required for that finding. Individual pulse, blood pressure and symptoms still matter, particularly with other interacting medicines.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.