Buprenorphine and Linezolid: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Monoamine oxidase inhibition with opioid-related serotonergic or CNS toxicity.
Clinical significance and safety
Buprenorphine with linezolid can cause serious opioid or serotonergic toxicity; the opioid label advises against use with MAO inhibitors and warns about recent MAOI treatment. A clinician should review the exact products and timing; do not start, stop or switch either medicine independently. Very slow breathing, inability to wake or collapse requires emergency help.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.