Co-Diovan 160 mg/12.5 mg and Oxycodone: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Opioid-induced antidiuretic hormone release can reduce diuretic response.
Clinical significance and safety
Opioids such as oxycodone may reduce the diuretic response to hydrochlorothiazide; the prescriber may need to review urine output, fluid status and blood pressure. Do not alter either treatment independently; report an unexpected reduction in urine output, swelling or a change in blood pressure to the clinical team.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.