Warfarin sodium (Coumadin 2 mg) and Erlotinib: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Erlotinib with coumarin anticoagulation has been associated with increased INR and bleeding.
Clinical significance and safety
Coumadin 2 mg contains warfarin. Increased INR and serious bleeding, including fatal cases, have been reported with erlotinib and coumarin anticoagulants. Clotting tests require regular clinical monitoring, and unusual bleeding or bruising should be reported promptly; do not change warfarin or erlotinib without the treating team.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.