Duloxetine hydrochloride (Cymbalta 30 mg) and Methadone: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Serotonin-syndrome warning for concomitant serotonergic medicines.
Clinical significance and safety
The methadone label includes this SNRI in its serotonergic-drug warning; serotonin syndrome has been reported with such combinations. A prescriber or pharmacist should review the combination; do not independently stop, start or change either medicine.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.