Daridorexant and Clarithromycin (Klacid 500 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Strong CYP3A4 inhibition increases daridorexant exposure and the risk of prolonged impairment.
Clinical significance and safety
Clarithromycin can increase daridorexant exposure through strong CYP3A4 inhibition. The daridorexant label advises avoiding strong inhibitors because adverse effects and daytime impairment may increase. A prescriber should review the sleep treatment before these medicines are combined.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.