Darunavir and Trazodone hydrochloride (Desyrel 50 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
The boosted regimen can increase exposure to the named antidepressant.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), this antidepressant may cause more dizziness, low blood pressure or fainting. Prescriber-led review is needed, particularly with additional sedating medicines.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.