Darunavir and Fentanyl: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Strong CYP3A inhibition increases fentanyl or oxycodone exposure.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), fentanyl or oxycodone may cause more opioid toxicity, including potentially fatal respiratory depression. Specialist review and monitoring are required; emergency help is needed for slow breathing or inability to wake.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.