Darunavir and Quetiapine fumarate (Ketilept 200 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
The boosted regimen can greatly increase quetiapine exposure.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), quetiapine requires major regimen review. The label favors considering another antiretroviral plan and gives different instructions depending on which treatment is started; specialist management is essential.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.