Darunavir and Simvastatin (Lipex 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
CYP3A inhibition markedly increases exposure to the named sensitive medicine.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), this named combination is contraindicated because exposure can rise enough to cause serious toxicity. The prescriber must review another plan; unboosted darunavir is not an equivalent alternative.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.