Darunavir and Pravastatin sodium (Lipostat 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
The boosted regimen increases exposure to the named statin.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), this statin needs careful prescribing and muscle-toxicity monitoring. Restrictions differ between statins; the exact product must be checked instead of treating the class as interchangeable.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.