Darunavir and Omeprazole (Losec 40 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Omeprazole exposure may decrease with the boosted regimen.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), monitor whether omeprazole remains effective. The prescriber should review reduced effect; this is different from the contraindication between oral rilpivirine and proton-pump inhibitors.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.