Darunavir and Mexiletine (Mexiletine (Meksiletin)): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
The boosted regimen can increase exposure to the named antiarrhythmic.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), this antiarrhythmic requires specialist review and concentration monitoring where available. Potential cardiac toxicity makes unsupervised changes inappropriate.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.