Darunavir and Rifampicin (Rifcap 300 mg Kapsül): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Rifampin induction lowers darunavir exposure despite ritonavir boosting.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), rifampin is contraindicated because reduced antiviral exposure can cause loss of effect and resistance. HIV and tuberculosis treatment must be coordinated by the prescribing teams.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.