Darunavir and Rilpivirine: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Ritonavir-boosted darunavir increases rilpivirine exposure through CYP3A inhibition.
Clinical significance and safety
The EDURANT label reports increased rilpivirine exposure with ritonavir-boosted darunavir without a routine adjustment requirement. This does not authorize combining complete HIV regimens independently and must not be generalized to another booster.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.