Darunavir and Carbamazepine (Tegretol CR 200 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Carbamazepine exposure may increase with the ritonavir-boosted regimen.
Clinical significance and safety
For ritonavir-boosted darunavir (PREZISTA/ritonavir), carbamazepine concentrations and clinical effects require monitoring. This ritonavir-specific advice must not replace the different rules that can apply to cobicistat-boosted darunavir.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.