Dasatinib and Famotidine (Famodin 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Famotidine increases gastric pH and reduces absorption of conventional dasatinib tablets.
Clinical significance and safety
Famodin 20 mg contains famotidine, an H2 blocker. The SPRYCEL tablet label advises against H2-blocker coadministration because dasatinib exposure may fall. The oncology pharmacist should arrange an appropriate stomach-symptom plan for the exact dasatinib product.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.