Dasatinib and Esomeprazole (Nexium 40 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Proton pump inhibition raises gastric pH and can reduce absorption of conventional dasatinib tablets.
Clinical significance and safety
Nexium 40 mg is a proton pump inhibitor. The SPRYCEL tablet label advises against coadministration because exposure and treatment effectiveness can fall. These instructions concern conventional SPRYCEL-type tablets; a different time of day does not remove the need for a formulation-specific review.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.