Trazodone hydrochloride (Desyrel 50 mg) and Lasmiditan: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Combined serotonergic effects can increase the risk of serotonin syndrome.
Clinical significance and safety
Lasmiditan with Trazodone may increase the risk of serotonin syndrome. The label advises caution with serotonergic antidepressants and related medicines; this is not a claim that every combination causes the syndrome. Fever, marked agitation, muscle rigidity, tremor or poor coordination after use require urgent medical assessment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.