Dolutegravir and Glucophage (Metformin) (Glucophage 500 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Renal transporter inhibition can increase metformin exposure.
Clinical significance and safety
Dolutegravir can increase metformin exposure, including when metformin is part of a combination tablet. The prescriber should review kidney function, glucose control and tolerability when either drug is started or stopped; do not adjust either drug independently.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.