Dolutegravir and Oxcarbazepine (Oxcarbazepine (Okskarbazepin)): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Enzyme induction may reduce dolutegravir exposure.
Clinical significance and safety
The TIVICAY label advises avoiding dolutegravir with phenytoin or oxcarbazepine because exposure may decrease and data are insufficient for a general dosing recommendation. The HIV and seizure-treatment teams should review the combination before either medicine is changed.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.