Efavirenz and Clarithromycin (Klacid MR 500 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Efavirenz changes clarithromycin exposure and its metabolite profile.
Clinical significance and safety
Efavirenz reduces clarithromycin and increases its metabolite. The label advises considering an alternative antibiotic because of QT-prolongation risk; the prescriber should assess the whole regimen.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.