Efavirenz and Ciclosporin (Sandimmun Neoral 100 mg Yumuşak Jelatin Kapsül): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Efavirenz induction can lower immunosuppressant exposure.
Clinical significance and safety
Efavirenz can lower cyclosporine or tacrolimus concentrations and jeopardize immunosuppression. Close concentration monitoring is needed when efavirenz starts or stops, coordinated by the transplant and HIV teams.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.