Efavirenz and Voriconazole (Voriconazole (Vorikonazol)): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Efavirenz reduces voriconazole exposure while voriconazole increases efavirenz exposure.
Clinical significance and safety
Standard-dose efavirenz and voriconazole should not be coadministered. The label describes a formulation-specific specialist-managed alternative when necessary; do not attempt this by splitting or adjusting tablets independently.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.