Efavirenz and Bupropion hydrochloride (Wellbutrin XR 300 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Efavirenz induction reduces exposure to the named antidepressant.
Clinical significance and safety
Efavirenz can reduce bupropion or sertraline exposure. The prescriber should monitor antidepressant response when efavirenz is started or stopped and make any necessary change; do not increase antidepressant doses independently.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.