Erlotinib and Famotidine (Gastrofam 40 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
H2-receptor blockade raises gastric pH and may reduce erlotinib absorption.
Clinical significance and safety
Gastrofam 40 mg is an H2 blocker that can reduce stomach acidity, a condition that lowers erlotinib absorption. The label distinguishes H2 blockers from proton pump inhibitors and calls for a prescriber-directed administration schedule if an H2 blocker is required. The exact famotidine–erlotinib pair was not the named study; the warning follows the labelled H2-blocker class effect.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.