Famotidine (Famodin 20 mg) and Rilpivirine: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
H2 blockade increases gastric pH and may reduce oral rilpivirine exposure.
Clinical significance and safety
Famotidine can reduce oral rilpivirine absorption when taken at an unsuitable interval. A pharmacist should arrange the label-specific timing plan; this differs from the contraindication applying to proton-pump inhibitors.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.