Imatinib and Atorvastatin calcium (Lipitor 40 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
CYP3A inhibition by imatinib may increase atorvastatin exposure.
Clinical significance and safety
Lipitor 40 mg contains atorvastatin, a statin metabolized through CYP3A. The GLEEVEC label warns that concentrations of certain CYP3A-metabolized statins can increase. A medication review is appropriate; new marked muscle pain, weakness or dark urine should be assessed.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.