Imatinib and Simvastatin (Zocor 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Imatinib inhibits CYP3A-mediated simvastatin metabolism, increasing statin exposure.
Clinical significance and safety
Zocor 20 mg contains simvastatin. A clinical interaction study in the GLEEVEC label found increased simvastatin exposure with imatinib. The treating team should review lipid-lowering treatment and investigate new unexplained muscle pain, weakness or dark urine.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.