Verapamil hydrochloride (İsoptin 120 mg) and Morphine: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
P-glycoprotein inhibition may increase oral morphine exposure.
Clinical significance and safety
Verapamil is a P-glycoprotein inhibitor named in the oral morphine label and can increase morphine exposure, potentially worsening sedation, hypotension and breathing suppression. A prescriber or pharmacist should review the combination; do not independently stop, start or change either medicine.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.