Omeprazole (Losec 40 mg) and Rilpivirine: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Increased gastric pH reduces oral rilpivirine absorption.
Clinical significance and safety
This proton-pump inhibitor is contraindicated with oral rilpivirine because reduced absorption can lead to loss of viral control and resistance. These oral-product rules must not be generalized to injectable rilpivirine; ask the HIV prescriber to review the precise acid-suppressing treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.