Clarithromycin (Macrol 500 mg) and Rilpivirine: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Macrolide CYP3A inhibition increases rilpivirine exposure, with additional QT concerns.
Clinical significance and safety
Clarithromycin is expected to increase rilpivirine concentrations and also carries torsade-de-pointes risk. The label advises considering an alternative antibiotic where possible; the prescriber should review the oral HIV regimen and cardiac-risk factors.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.