Tacrolimus (Prograf 1 mg Sert Jelatin Kapsül) and Tofacitinib: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Added immunosuppression is a concern with tofacitinib and tacrolimus.
Clinical significance and safety
The tofacitinib label specifically names tacrolimus among immunosuppressive drugs that should not be combined with tofacitinib. Prograf 1 mg Sert Jelatin Kapsül contains systemic tacrolimus; specialist review is required because of added immunosuppression and infection risk. Do not independently interrupt transplant or inflammatory-disease treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.