Carbamazepine (Tegretol CR 400 mg) and Voclosporin: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
CYP3A4 induction can lower voclosporin exposure and reduce response.
Clinical significance and safety
Tegretol CR 400 mg contains a strong or moderate CYP3A inducer. Voclosporin labeling recommends avoiding these inducers because exposure and effectiveness can fall. The prescribing teams should reconcile the medicines rather than the patient independently stopping treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.