Tenofovir disoproxil fumarate and Diclofenac (Voltaren SR 75 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Systemic NSAID-related renal stress can increase the risk of TDF-associated kidney injury.
Clinical significance and safety
This record applies to systemic NSAID use of Voltaren SR 75 mg. The TDF label highlights acute kidney injury with high-dose or multiple NSAIDs, especially with pre-existing renal risk; it does not state that every dose is absolutely contraindicated. A clinician should review renal function, total NSAID exposure and monitoring before this combination or additional over-the-counter painkillers are used.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.