Voclosporin and Simvastatin (Zocor 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Voclosporin inhibits OATP transport and can increase exposure to susceptible statins.
Clinical significance and safety
Zocor 20 mg contains a statin named in the voclosporin interaction guidance. Increased exposure can raise muscle-toxicity risk, including rhabdomyolysis, so the prescriber may need closer monitoring or a statin-regimen adjustment. Report unexplained muscle pain, weakness or dark urine promptly.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.