Celebrex 200 mg (Celecoxib) and Rivaroxaban (Xarelto 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Systemic NSAIDs add to the bleeding risk of rivaroxaban.
Clinical significance and safety
Celebrex 200 mg (Celecoxib) and Rivaroxaban (Xarelto 20 mg): Rivaroxaban product information calls for caution with NSAIDs because bleeding risk can increase. A prescriber should review whether the analgesic is needed, relevant ulcer or bleeding history and other medicines affecting haemostasis. Black stools, vomiting blood or bleeding that will not stop requires urgent assessment. Do not stop prescribed rivaroxaban on your own. This record concerns oral systemic NSAIDs, not an identical exposure or risk estimate for topical diclofenac.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.